Why the study?
Does etomidate affect the intrinsic contractility of left ventricular papillary muscle in normal and cardiomyopathic hamsters?
Population
Left ventricular papillary muscle from normal hamsters and those with cardiomyopathy
Comparison
Etomidate administered in vitro vs Baseline conditions and normal hamster papillary…
Design
Preclinical
Authors
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Etomidate shows minimal direct effects in this hamster model; leaves open translation to human myocardium and clinical use.
Does etomidate affect the intrinsic contractility of left ventricular papillary muscle in normal and cardiomyopathic hamsters?
Etomidate has minimal effects on the intrinsic mechanical properties of both normal and cardiomyopathic hamster cardiac papillary muscles, suggesting it does not significantly depress myocardial contractility.
Riou et al. (1990) studied this question.
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