Why the study?
Does etomidate affect the contractility of failing and nonfailing human heart muscle?
Population
Human cardiac muscle obtained from the left ventricle and right atrium of 12 patients undergoing cardiac…
Comparison
Etomidate (0.04–80 μM) vs Baseline and solvent (propylene glycol)
Design
Preclinical
Authors
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Supports safety at clinical doses in isolated myocardium; leaves open in vivo effects in failing hearts.
Does etomidate affect the contractility of failing and nonfailing human heart muscle?
Etomidate exerts a dose-dependent negative inotropic effect on human myocardium only at supraclinical concentrations, suggesting it is unlikely to cause clinically significant myocardial depression even in patients with cardiac dysfunction.
Šprung et al. (2000) studied this question.
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