Population
Isolated ferret ventricular myocardium (right ventricular papillary muscles) and frog ventricular myocardium
Comparison
Etomidate after beta-adrenoceptor blockade, with… vs Control muscles not exposed to etomidate
Design
Preclinical
Authors
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Etomidate unlikely to impair contractility at clinical concentrations; leaves open in vivo relevance of Ca++ effects in humans.
Etomidate exerts a direct negative inotropic effect by inhibiting transsarcolemmal Ca++ influx, but only at concentrations at least one order of magnitude larger than those used clinically.
Mattheussen et al. (1993) studied this question.
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