Why the study?
Does etomidate reduce the developed force in rabbit papillary muscles?
Population
Rabbit papillary muscles
Comparison
Etomidate (2 and 4 mg/L) vs Baseline/control conditions under various…
Design
Preclinical
Authors
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Etomidate depresses rabbit papillary muscle at supratherapeutic doses; leaves open clinical relevance in patients with normal hearts.
Does etomidate reduce the developed force in rabbit papillary muscles?
Etomidate inhibits extracellular Ca2+ influx to produce a negative inotropic effect, but at concentrations higher than clinical levels, suggesting it is unlikely to cause negative inotropism in patients with normal hearts.
Komai et al. (1985) studied this question.
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