Key result
Caffeine ingestion reduces total perfusion defects on dipyridamole MPS by ~45% vs baseline.
Why the study?
There is no consensus on whether and how long caffeine should be interrupted before dipyridamole myocardial perfusion gated SPECT testing despite caffeine diminishing dipyridamole's effect.
Comparison
Dipyridamole gated MPS before and after caffeine ingestion
Design
Observational paired comparison study
Authors
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Caffeine may blunt dipyridamole perfusion defects on gated MPS; hypothesis-generating for pre-test abstinence pending larger confirmatory studies.
Absolute Event Rate: 34% vs 62%
p-value: p=<0.05
Yaylalı et al. (2013) studied Coronary artery disease (n=36). Caffeine ingestion vs. Baseline (before caffeine ingestion) was evaluated on Percentage of total perfusion defects (p=<0.05). Caffeine ingestion significantly reduced the percentage of total perfusion defects on dipyridamole stress gated MPS compared to baseline (34% vs 62%, p<0.05).
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