Why the study?
Does caffeine attenuate the hemodynamic response to dipyridamole infusion in normotensive volunteers?
Population
8 normotensive volunteers
Comparison
Caffeine prior to dipyridamole infusion vs Placebo prior to dipyridamole infusion, and…
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
acute (during tests)
Authors
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Recommend caffeine abstinence before dipyridamole stress testing; extends RCT evidence of adenosine antagonism in volunteers.
Does caffeine attenuate the hemodynamic response to dipyridamole infusion in normotensive volunteers?
Caffeine dose-dependently attenuates the hemodynamic response to dipyridamole, which may have clinical implications for diagnostic dipyridamole use in myocardial imaging.
Smits et al. (1991) studied this question.
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