Exploring the synthetic developments and pharmacological potential of 2-amino/hydrazino-4-arylthiazoles: a review

This is the authors' abstract. We don't add key points for this paper.

2-Amino/hydrazinothiazoles represent an essential class of azole motifs associated with various pharmacological properties. They are fundamental components of several FDA-approved drugs and biologically valuable natural products. The present review is focused mainly on 2-amino/hydrazino-4-arylthiazole derivatives that have diversified biological potentials like anti-bacterial, DNA photocleavage, anti-trichomonal, anti-viral, anti-hypertensive, anti-leishmanial, anti-cancer, etc. It mainly describes synthetic developments and medicinal applications of these heterocycles from 2002 onwards. Recent synthetic advancements have also been discussed, including metal-free and catalyst-free, microwave-assisted, greener, and environment-friendly protocols for such motifs. This article also highlights the structural modifications in these heterocycles and their effects on medicinal properties. It would benefit synthetic and medicinal chemists in developing novel biologically active compounds with reduced toxicity.