Pola Penggunaan Kombinasi CCB–ACEI dan Diuretik–ARB Terhadap Karakteristik Pasien Gagal Ginjal Kronik

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Chronic Kidney Disease with Hypertension (n=81). Intervention: Age and antihypertensive combination therapy (CCB-ACEI vs Diuretic-ARB). Primary outcome: Relationship between patient age and the selection of antihypertensive combination therapy (p=0.037).

Q: What does this research mean for the field?

The selection of antihypertensive combination regimens in hospitalized chronic kidney disease patients is significantly associated with age, with diuretic-ARB combinations being the predominant therapy overall and CCB-ACEI used more frequently in patients aged 47 to 61 years. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Putri Sabrina Mawarda; Eko Retnowati; Intan Adevia Rosnarita

doi:10.31004/joecy.v6i1.9893

April 16, 2026Journal of Innovative and Creativity (Joecy)Open Access

Pola Penggunaan Kombinasi CCB–ACEI dan Diuretik–ARB Terhadap Karakteristik Pasien Gagal Ginjal Kronik

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Why the study?

The selection of appropriate antihypertensive combinations in CKD patients is crucial to maintain hemodynamic stability and prevent renal function deterioration, but patterns and patient characteristics influencing therapy choice are not well described.

Does age influence the selection of CCB-ACEI versus Diuretic-ARB combination antihypertensive therapy in hospitalized patients with chronic kidney disease?

Study Design

Type

Cross-Sectional (n=81)

Multicenter

No

Structured PICO

Does age influence the selection of CCB-ACEI versus Diuretic-ARB combination antihypertensive therapy in hospitalized patients with chronic kidney disease?

P

Population

81 hospitalized patients aged 17–85 years with chronic kidney disease and hypertension who received combination antihypertensive therapy.

E

Exposure

Antihypertensive combination therapy: Diuretic-ARB (predominantly spironolactone-candesartan or furosemide-candesartan) or CCB-ACEI (predominantly ramipril-amlodipine or ramipril-nicardipine).

O

Outcome

Pattern of antihypertensive combination use and the relationship between patient age and the selection of CCB-ACEI versus Diuretic-ARB therapy.

Main Result

p-value: p=0.037

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Implication

In hospitalized CKD patients, Diuretic-ARB is the most frequently prescribed antihypertensive combination (80.2%), and its selection is significantly influenced by patient age and individual hemodynamic needs.

Abstract

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Discussion

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Cite This Study

Mawarda et al. (2026) conducted a cross-sectional in Chronic Kidney Disease with Hypertension (n=81). Age and antihypertensive combination therapy (CCB-ACEI vs Diuretic-ARB) was evaluated on Relationship between patient age and the selection of antihypertensive combination therapy (p=0.037).

synapsesocial.com/papers/6ac72a1436c8cd5d094bf101 https://doi.org/10.31004/joecy.v6i1.9893

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Pola Penggunaan Kombinasi CCB–ACEI dan Diuretik–ARB Terhadap Karakteristik Pasien Gagal Ginjal Kronik

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Pola Penggunaan Kombinasi CCB–ACEI dan Diuretik–ARB Terhadap Karakteristik Pasien Gagal Ginjal Kronik

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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