Evolving Science on Cardiovascular Disease Among Hispanic/Latino Adults

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Cardiovascular and pulmonary diseases risk factors (n=16415). Intervention: Hispanic/Latino background (HCHS/SOL cohort). Primary outcome: All-cause mortality, fatal and non-fatal CVD and pulmonary disease, and exacerbation of asthma and COPD over time.

Q: What does this research mean for the field?

The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) provides essential longitudinal data characterizing the prevalence of, trajectories in, and determinants of cardiovascular disease risk factors and chronic condition burdens across diverse US Hispanic/Latino backgrounds. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Amber Pirzada; Jianwen Cai; Gerardo M HEISS; Daniela Sotres‐Alvarez; Linda C. Gallo; Marston Youngblood; Larissa M. Avilés-Santa; Hector M. González; Carmen R. Isasi; Robert C. Kaplan; James Phillip Lash; David J. Lee; Maria Magdalena Llabre; Frank J. Penedo; Carlos J. Rodríguez; Neil Schneiderman; Tamar Sofer; Gregory A. Talavera; Bharat Thyagarajan; Sylvia W Wassertheil-Smoller; Martha L. Daviglus

doi:10.1016/j.jacc.2023.02.023

Key result

Hispanic and Latino adults show high CV risk burden, with ~26% hypertension prevalence varying by background.

n=16,415

Why the study?

Comprehensive data on risk factors for cardiovascular disease and other chronic diseases among diverse Hispanic/Latino persons in the US were lacking.

Key Points

To describe the design, objectives, and findings of the Hispanic Community Health Study/Study of Latinos and its ancillary studies in assessing cardiovascular disease risk factors and chronic conditions.
Multicenter longitudinal community-based cohort study using probability sampling of adults from diverse Hispanic/Latino backgrounds across selected regions in the US.
Comprehensive examinations at baseline and a 6-year follow-up assessing biologic, genetic, sociocultural, lifestyle, echocardiographic, and neurocognitive factors.
At baseline, 80% of men and 71% of women had at least one adverse major cardiovascular risk factor, whereas favorable levels for all major risk factors were present in only 5.1% of men and 11.2% of women.
Over 6 years of follow-up, the age-adjusted incidence of diabetes was 22.1 per 1,000 person-years, and hypertension control at baseline was 37.5%, with significant variation across background heritages.
Echocardiographic studies showed clinical heart failure with left ventricular systolic and diastolic dysfunction in 7.3% and 3.6% of participants, respectively, with 96% of detected cardiac dysfunction previously unrecognized.

Study Design

Type

Cohort (n=16,415)

Multicenter

Yes

Structured PICO

P

Population

16,415 diverse Hispanic/Latino adults aged 18-74 years living in four US communities, followed longitudinally to assess cardiovascular and pulmonary disease risk factors and outcomes.

O

Outcome

All-cause mortality, fatal and non-fatal CVD and pulmonary disease, and exacerbation of asthma and COPD over timehard clinical

The HCHS/SOL study provides comprehensive longitudinal data highlighting the significant burden and diverse profiles of cardiovascular and pulmonary risk factors among various Hispanic/Latino populations in the US.

Limitations

The sampling design does not allow inferences to the entire Hispanic/Latino population across the US.
The absence of participants of non-Hispanic/Latino backgrounds precludes direct comparison with non-Hispanic white US adults.

Implication

May warrant background-specific CV risk assessment in Hispanic/Latino adults; leaves open whether tailored strategies reduce disparities.

Abstract

The landmark, multicenter Hispanic Community Health Study/Study of Latinos (HCHS/SOL), is the largest, most comprehensive, longitudinal community-based cohort study to date of diverse Hispanic/Latino persons in the US. The HCHS/SOL aimed to address the dearth of comprehensive data on risk factors for cardiovascular disease (CVD) and other chronic diseases in this population and has expanded considerably in scope since its inception. This paper describes the aims/objectives and data collection of the HCHS/SOL and its ancillary studies to date and highlights the critical and sizeable contributions made by the study to understanding the prevalence of and changes in CVD risk/ protective factors and the burden of CVD and related chronic conditions among adults of diverse Hispanic/Latino backgrounds. The continued follow-up of this cohort will allow in-depth investigations on cardiovascular and pulmonary outcomes in this population, and data from the ongoing ancillary studies will facilitate generation of new hypotheses and study questions.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Pirzada et al. (2023) conducted a cohort in Cardiovascular and pulmonary diseases risk factors (n=16,415). Hispanic/Latino background (HCHS/SOL cohort) was evaluated on All-cause mortality, fatal and non-fatal CVD and pulmonary disease, and exacerbation of asthma and COPD over time. The HCHS/SOL cohort revealed a high baseline burden of cardiovascular risk factors among 16,415 diverse Hispanic/Latino adults, including a 25.5% prevalence of hypertension and 16.9% prevalence of diabetes, which varied significantly by national background.

synapsesocial.com/papers/6acf1527e9cf455829e373fc https://doi.org/10.1016/j.jacc.2023.02.023

View Full Paper

Ask AI

Bookmark

Share

Evolving Science on Cardiovascular Disease Among Hispanic/Latino Adults

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Evolving Science on Cardiovascular Disease Among Hispanic/Latino Adults

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading