Key result
Higher TG/HDL ratio moderately correlates with increased TyG index in uncontrolled type 2 diabetes.
Why the study?
Data on the relationship between the TG/HDL-C ratio and the TyG index as indicators of insulin resistance are limited in patients with uncontrolled type 2 diabetes mellitus.
Cross-Sectional (n=40)
No
In patients with uncontrolled type 2 diabetes, the TG/HDL ratio and TyG index show a significant moderate positive correlation, suggesting they may serve as complementary markers of insulin resistance and cardiometabolic risk.
Answers are grounded in this paper and cite their sources.
May support TG/HDL ratio as accessible TyG surrogate in uncontrolled T2DM; hypothesis-generating pending prospective validation.
Background: Type 2 diabetes mellitus is a global metabolic disorder marked by insulin resistance and higher cardiovascular risk. Recent research highlights simple, accessible biomarkers, including the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and the triglyceride-glucose index (TyG), as indicators of insulin resistance. However, data on the relationship between these markers are limited, especially in patients with uncontrolled type 2 diabetes mellitus. This research to determine the relationship between the TG/HDL-C ratio and the TyG index in patients with uncontrolled type 2 diabetes mellitus. Methods: This descriptive-analytical, cross-sectional study included 40 participants selected by purposive sampling who met the inclusion criteria. TG, HDL, and glucose levels were measured automatically using a chemistry analyzer with enzymatic methods. Data were analyzed using nonparametric statistical tests, specifically the Spearman correlation test. Results: The mean TG/HDL ratio was 4.26, and the TyG index was 9.87, indicating insulin resistance among participants. A moderate positive correlation was observed between the TG/HDL ratio and the TyG index (p = 0.003; r = 0.461). These results suggest both parameters reflect similar metabolic pathways and can serve as indicators of insulin resistance. Conclusion: Spearman correlation analysis shows a significant association between the TG/HDL ratio and the TyG index in patients with uncontrolled type 2 diabetes.
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Sihotang et al. (2026) conducted a cross-sectional in Uncontrolled type 2 diabetes mellitus (n=40). TG/HDL-C ratio was evaluated on Correlation between TG/HDL ratio and TyG index (r = 0.461, p=0.003). The TG/HDL ratio showed a moderate positive correlation with the TyG index in patients with uncontrolled type 2 diabetes mellitus.
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