Key result
In patients treated with percutaneous coronary intervention, a post-stent maximum 4-mm lipid core burden index greater than 400 was significantly associated with higher cumulative target vessel failure.
Why the study?
The relationship between NIRS-derived lipid burden and target vessel failure, particularly non-target lesion failure, after PCI remains unclear.
Does post-PCI residual lipid-rich plaque evaluated by NIRS-IVUS predict target vessel failure in patients undergoing percutaneous coronary intervention?
Observational (n=151)
No
Does post-PCI residual lipid-rich plaque evaluated by NIRS-IVUS predict target vessel failure in patients undergoing percutaneous coronary intervention?
p-value: p=0.0272
Residual lipid-rich plaque with a MaxLCBI4mm > 400 after stenting identifies patients at a significantly increased risk for subsequent target vessel failure, particularly at non-target lesions.
Lipid-rich plaque detected by near-infrared spectroscopy combined with intravascular ultrasound (NIRS-IVUS) may be related to adverse outcomes after percutaneous coronary intervention (PCI). The relationship between NIRS-derived lipid burden and target vessel failure (TVF)—particularly non-target lesion failure (TLF) TVF—remains unclear.
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Tatsuru et al. (2026) conducted an observational in Coronary Artery Disease (n=151). Post-PCI Maximum 4-mm lipid core burden index (MaxLCBI 4mm) > 400 vs. Post-PCI MaxLCBI 4mm ≤ 400 was evaluated on Target vessel failure (TVF) (p=0.0272). In patients treated with percutaneous coronary intervention, a post-stent maximum 4-mm lipid core burden index greater than 400 was significantly associated with higher cumulative target vessel failure.
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