Key result
Printed organic field-effect transistors non-invasively record cardiomyocyte action potentials with a ~91% success rate.
Why the study?
Extracellular electrophysiological recordings from cardiac cells using field-effect transistors were investigated to understand the coupling mechanisms and validate recording quality compared to gold standards.
Supports non-invasive AP recording in hiPSC-cardiomyocyte models; leaves open clinical translation pending validation.
Extracellular electrophysiological recordings were made from cardiac cells cultured for up to seven days over microfabricated arrays of field-effect transistors. The recorded signals can be separated mainly into two types of cell transistor couplings: one that can be explained entirely by purely passive circuitry elements, and a second where voltage-gated ion channels contribute greatly to the measured extracellular signal.
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Sprößler et al. (1999) studied In vitro cardiac electrophysiology. Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) vs. Patch clamp and Microelectrode Arrays (MEAs) was evaluated on Successful recording of action potential waveforms. Printed electrolyte-gated organic field-effect transistors successfully and non-invasively recorded action potentials from human induced pluripotent stem cell-derived cardiomyocytes with a 90.7% success rate.
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