Why the study?
Heart failure affects women and men differently, and its prevalence and mortality rates are expected to increase rapidly with aging populations.
Recognizing significant sex differences in heart failure pathophysiology, risk factors, and treatment responses is essential for providing individualized care and highlights the urgent need to increase female representation in clinical trials.
Supports sex-informed HFpEF care; leaves open generalizability of trial results given female underrepresentation.
Heart failure is a life-threatening condition that affects women and men differently. Due to increases in mean patient age, heart failure prevalence and mortality rates are expected to increase rapidly. Heart failure is characterised as a syndrome leading to a high burden of disease for the individual patient and increased healthcare costs for society related to rehospitalisation. This review highlights sex differences across the entire spectrum of heart failure.
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Wijesinghe et al. (2025) conducted a review in Heart failure. Female sex vs. Male sex was evaluated.
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