Key result
Intravenous ethanol acutely lowers heart rate and alters key electrocardiographic parameters.
Why the study?
The effects of intravenous ethanol at different concentrations on the electrocardiogram of New Zealand White rabbits were not well characterized.
Answers are grounded in this paper and cite their sources.
Acute IV ethanol may pose cardiotoxicity risks in rabbits; hypothesis-generating and should not change human practice.
The present study was undertaken to study the effects of intra-venous (i.v.) ethanol (25%, 50% and 100%) on Electrocardiogram of New Zealand White rabbits. Twelve healthy and clinically normal New Zealand White rabbits of either sex, weighing between 2-3 kg and aged between 1-2 years were selected for the present study. 1 ml of ethanol (25%, 50% and 100%) was injected i.v. in the ear vein of the rabbit and ECG recordings were taken for 50 minutes. Rabbits exhibited a significant decrease in heart rate following the injection of 25% and 50% ethanol and the heart rate remained significantly (P<0.01) depressed for a period of 30 minutes. Low P-wave amplitude was observed. QRS amplitudes have increased significantly in 25% and 50% ethanol treated group. Increased QRS voltage, and prolonged ventricular activation time, likely represents left ventricular hypertrophy. But QRS amplitude has decreased significantly in 100% ethanol treatment. T wave amplitudes significantly increase in 25% and 50% treatment group and decrease in 100% treatment group. QT interval indicating the total duration of electrical activity in the ventricles was significantly increased compared with that of control group (50% treated group).
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Ahmed et al. (2019) studied Healthy (n=12). Intravenous ethanol vs. Baseline (normal electrocardiogram recorded beforehand) was evaluated on Heart rate (p=<0.01). Intravenous injection of 25% and 50% ethanol decreased the heart rate for 30 minutes, alongside significant alterations in P, QRS, and T wave amplitudes and QT interval prolongation.
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