Key result
Biodegradable polymer DES linked to ~6-point higher strut coverage than durable polymer DES.
Why the study?
Different stent types implanted in STEMI patients may influence long-term prognosis by affecting vessel healing after stenting, but comparative data on vessel healing among biodegradable polymer DES, durable polymer DES, and BMS are limited.
Observational (n=50)
Observer-blinded
No
Absolute Event Rate: 94.9% vs 89%
p-value: p=<0.001
May favor biodegradable over durable polymer DES for healing in STEMI; hypothesis-generating, needs prospective trials before practice change.
BACKGROUND: Different stents implantation in ST-segment elevation myocardial infarction (STEMI) patients may influence the long term prognosis by affecting vessel healings after stenting. The aim of this study was to evaluate the vessel healings after implantation of drug eluting stents (DES) with biodegradable or durable polymer or of bare-metal stents (BMS) in patients with acute STEMI. METHODS: This study included 50 patients, who underwent follow up angiogram and optical coherence tomography (OCT) assessment about one year after percutaneous coronary intervention (PCI) for STEMI. According to the initial stents types, these patients were classified to durable (n = 19) or biodegradable polymer sirolimus-eluting stents (n = 15), or BMS (n = 16) groups. The conditions of stent struts coverage and malapposition were analyzed with OCT technique. RESULTS: A total of 9003 struts were analyzed: 3299, 3202 and 2502 from durable or biodegradable polymer DES, or BMS, respectively. Strut coverage rate (89.0%, 94.9% and 99.3%, respectively), malapposition presence (1.7%, 0.03% and 0 of struts, respectively) and average intimal thickness over struts (76 ± 12 µm, 161 ± 30 µm and 292 ± 29 µm, respectively) were significantly different among different stent groups (all P < 0.001). CONCLUSIONS: Vessel healing status in STEMI patients is superior after implantation of biodegradable polymer DES than durable polymer DES, while both are inferior to BMS.
No takes yet. Share an insight, caveat, or question.
Jin et al. (2016) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=50). Biodegradable polymer drug-eluting stents vs. Durable polymer drug-eluting stents and bare-metal stents was evaluated on Stent strut coverage rate (p=<0.001). Biodegradable polymer drug-eluting stents demonstrated a higher stent strut coverage rate (94.9%) than durable polymer stents (89.0%), though both were inferior to bare-metal stents (99.3%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: