Key result
Abdominal fat content (TA, VA, SA, VA/SA) positively correlated with both T1DM and T2DM, with VA/SA > 1 occurring in 40.48% of T2DM versus 2.18% of T1DM patients.
Why the study?
The study aimed to investigate abdominal fat distribution in Chinese subjects with diabetes and its correlation with different types of diabetes.
Does abdominal fat distribution measured by multi-slice spiral CT differ between type 1 and type 2 diabetes and correlate with metabolic parameters in a Chinese population?
Cross-Sectional (n=176)
Radiologists blinded to subjects' information
No
Does abdominal fat distribution measured by multi-slice spiral CT differ between type 1 and type 2 diabetes and correlate with metabolic parameters in a Chinese population?
MSCT-quantified abdominal fat content positively correlates with both T1DM and T2DM in Chinese patients, with T1DM characterized predominantly by subcutaneous fat accumulation and T2DM by higher visceral-to-subcutaneous fat ratios.
Answers are grounded in this paper and cite their sources.
No immediate practice change; leaves open whether visceral-to-subcutaneous ratios predict outcomes or guide therapy in diabetes.
To investigate abdominal fat distribution in Chinese subjects with diabetes and its correlation with different types of diabetes. A total of 176 diabetic subjects were enrolled, 92 with type 1 and 84 with type 2, with a mean age of 27.41 and 49.3 yrs. No subject has history of severe diseases. Multi-slice CT was used to measure total abdominal adipose (TA) and visceral adipose (VA) tissues. Subcutaneous adipose (SA) tissue was obtained by subtracting VA from TA. There were differences between subjects with T1DM and T2DM for TA, VA, SA, VA/SA, body mass index (BMI), triglyceride (TG) and high density lipoprotein, but not total Cholesterol or low density lipoprotein. There were positive correlations between TA, VA, SA, VA/SA and T1DM and T2DM (P < 0.05 and r > 0.86). In subjects with T1DM, VA was negatively correlated with HDL, positively with BMI and age, and SA was positively correlated with BMI and sex (P < 0.05 and r > 0.86 for all). In subjects with T2DM, VA was positively correlated to BMI, TG and age, and SA was positively correlated to TG and sex (P < 0.05 and r > 0.86 for all). Abdominal fat content was positively correlated to diabetes in Chinese, which differs in different types of diabetes.
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Zhu et al. (2013) conducted a cross-sectional in Diabetes mellitus (Type 1 and Type 2) (n=176). Type 2 Diabetes Mellitus (vs Type 1 Diabetes Mellitus) and Abdominal Fat Distribution measured by MSCT vs. Type 1 Diabetes Mellitus was evaluated on Visceral to subcutaneous adipose tissue ratio (VA/SA) > 1 and correlation of abdominal adipose tissue (TA, VA, SA, VA/SA) with diabetes type (r > 0.86, p=< 0.05). Abdominal fat content (TA, VA, SA, VA/SA) positively correlated with both T1DM and T2DM, with VA/SA > 1 occurring in 40.48% of T2DM versus 2.18% of T1DM patients.
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