Key result
Endovascular therapy door-to-device time ≤90 minutes linked to ~51% higher odds of favorable 90-day recovery.
Why the study?
The American Heart Association sets a goal of performing 50% of endovascular therapy procedures with a door-to-device time of 90 minutes or less for direct arriving patients, and initiatives to improve these times require evidence of patient benefit to justify long-term adoption.
Does achieving a door-to-device time ≤90 minutes improve 90-day functional outcomes (mRS 0-2) in patients undergoing endovascular thrombectomy for ischemic stroke?
Cohort
Does achieving a door-to-device time ≤90 minutes improve 90-day functional outcomes (mRS 0-2) in patients undergoing endovascular thrombectomy for ischemic stroke?
Achieving a door-to-device time of 90 minutes or less during endovascular thrombectomy for ischemic stroke is significantly associated with better 90-day functional outcomes, supporting the AHA target.
Answers are grounded in this paper and cite their sources.
Supports current AHA door-to-device targets in acute ischemic stroke; leaves open the causal benefit of workflow acceleration pending prospective validation.
BACKGROUND: The American Heart Association (AHA) has a current goal of performing 50% of endovascular therapy (EVT) procedures with a door-to-device (DTD) time of 90 minutes or less for direct arriving patients. Initiatives to improve DTD times need evidence of patient benefit to justify long-term adoption. METHODS: We performed a retrospective study of patients who underwent endovascular thrombectomy for ischemic stroke. The likelihood of a favorable patient outcome was quantified for patients with a DTD time ≤90 minutes compared to patients with a DTD time >90 minutes. RESULTS: DTD ≤90 minutes was associated with an increased odds of having a more favorable (0-2) modified Rankin Score at 90-days (AOR, 1.51; 95% CI, 1.15-2.00; P = .004) post stroke compared to DTD >90 minutes. We did not find that DTD under or over 90 minutes had a significant association with discharge home (AOR, 1.21; 95% CI, 1.00-1.46; P = .051) or patients' length of stay (β, -0.48; 95% CI, -1.30-0.34; P = .20). CONCLUSIONS: Our study supports that EVT completed with DTD time ≤90 minutes was associated with better functional outcomes for patients.
No takes yet. Share an insight, caveat, or question.
Tarpley et al. (2026) conducted a cohort in Ischemic stroke. Endovascular therapy door-to-device time ≤90 minutes vs. Door-to-device time >90 minutes was evaluated on Favorable modified Rankin Score (0-2) at 90 days post stroke (AOR 1.51, 95% CI 1.15-2.00, p=0.004). Endovascular therapy door-to-device time ≤90 minutes increased odds of a favorable 90-day modified Rankin Score (0-2) compared to >90 minutes (AOR 1.51; 95% CI 1.15-2.00; P=.004).
Synapse has enriched 10 related papers. Consider them for comparative context: