Key result
Serum Apo A1 and lipid levels decline progressively with worsening MELD-Na scores in liver disease.
Why the study?
Liver cirrhosis progressively impairs hepatic synthetic function and alters lipid metabolism, and Apolipoprotein A1 may decrease with worsening dysfunction. This study evaluated the correlation of serum Apo A1 and fasting lipid-profile parameters with Child-Pugh and MELD-Na prognostic scores as supplementary markers of disease severity.
Do serum Apolipoprotein A1 and fasting lipid profile parameters correlate with disease severity as measured by Child-Pugh and MELD-Na scores in patients with liver cirrhosis?
Cross-Sectional (n=80)
Yes
Do serum Apolipoprotein A1 and fasting lipid profile parameters correlate with disease severity as measured by Child-Pugh and MELD-Na scores in patients with liver cirrhosis?
Serum Apo A1 and fasting lipid levels decrease progressively with worsening liver cirrhosis and inversely correlate with MELD-Na scores, supporting Apo A1 as a supplementary marker of hepatic dysfunction.
Answers are grounded in this paper and cite their sources.
Apo A1 inversely correlated with MELD-Na in cirrhosis; hypothesis-generating for its role as a supplementary marker, prospective validation required.
Background: Liver cirrhosis causes progressive impairment of hepatic synthetic function and produces substantial alterations in lipid and lipoprotein metabolism.Apolipoprotein A1 (Apo A1), the principal protein component of highdensity lipoprotein, may decrease with worsening hepatic dysfunction and could serve as a supplementary marker of disease severity.Aim and Objectives: To estimate serum Apo A1 and fasting lipid-profile parameters in patients with liver cirrhosis, calculate Child-Pugh and Model for End-Stage Liver Disease-Sodium (MELD-Na) scores, and determine the correlation of Apo A1 and lipid parameters with these prognostic measures. Materials and Methods:This hospital-based cross-sectional study included 80 patients with liver cirrhosis attending or admitted to hospitals attached to Bangalore Medical College and Research Institute between August 2022 and January 2024.Clinical assessment and relevant laboratory investigations, including fasting lipid profile and Apo A1, were performed.Child-Pugh classification and MELD-Na scores were determined, and their relationships with Apo A1 and lipid parameters were analysed.Results: The mean age was 44.53 ± 10.51 years, and 82.5% were males.Alcohol was the predominant aetiology (82.5%).Child-Pugh classes A, B and C comprised 1.3%, 23.8% and 75.0% of patients, respectively.The mean MELD-Na score was 24.28 ± 8.15.Mean total cholesterol, triglycerides, LDL, VLDL and HDL were 98.09 ± 42.13, 116.71 ± 43.81, 55.03 ± 29.39, 23.86 ± 9.28 and 17.54 ± 10.28 mg/dL, respectively.Mean Apo A1 was 48.22 ± 31.49mg/dL among 79 patients.Apo A1 differed significantly across Child-Pugh classes (p=0.013).All lipid parameters and Apo A1 differed significantly across MELD-Na categories (p=0.001each).Apo A1 demonstrated the strongest inverse correlation with MELD-Na score (, p<0.001).Conclusion: Apo A1 and lipid-profile parameters declined with increasing severity of liver cirrhosis.Apo A1 showed a particularly strong inverse relationship with MELD-Na score and may serve as a useful supplementary biochemical indicator of hepatic dysfunction when interpreted alongside established prognostic scores.
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A 2026 study conducted a cross-sectional in Liver cirrhosis (n=80). Serum Apolipoprotein A1 (Apo A1) and fasting lipid profile levels was evaluated on Correlation and comparison of serum Apo A1 and fasting lipid parameters with Child-Pugh and MELD-Na prognostic scores (p=<0.001). Serum Apo A1 and fasting lipid parameters declined across worsening MELD-Na categories, with Apo A1 showing the strongest inverse correlation with MELD-Na.
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