Key result
Neck subcutaneous fat thickness is positively associated with higher insulin resistance in overweight patients.
Why the study?
The association between neck subcutaneous adipose tissue thickness and insulin resistance, as well as its diagnostic value for metabolic disorders, needed evaluation.
Is neck subcutaneous adipose tissue (NSAT) thickness associated with insulin resistance (HOMA-IR) in overweight and obese adults compared to non-overweight individuals?
Cross-Sectional (n=617)
No
Is neck subcutaneous adipose tissue (NSAT) thickness associated with insulin resistance (HOMA-IR) in overweight and obese adults compared to non-overweight individuals?
Ultrasound-measured neck subcutaneous adipose tissue thickness is positively correlated with fasting insulin and HOMA-IR in overweight and obese individuals, suggesting its potential utility as a non-invasive imaging biomarker for early metabolic risk screening.
Answers are grounded in this paper and cite their sources.
Neck subcutaneous adipose tissue thickness was associated with insulin resistance markers; leaves open its value as an imaging biomarker pending prospective validation.
Objectives: This study aimed to investigate the association between neck subcutaneous adipose tissue (NSAT) thickness and insulin resistance (IR), and to evaluate the diagnostic value of NSAT for metabolic disorders.Methods: A total of 617 participants from Hongqiao Town were divided into two groups: an experimental group (EG) and a control group (CG).Ultrasonography (US) was adopted to measure NSAT thickness, and homeostatic model assessment-insulin resistance (HOMA-IR) was calculated to assess IR.Pearson correlation analysis was performed to analyze the correlation between NSAT and IR.Results: Male proportion (41.6% vs 24.7%), waist circumference (WC), hip circumference (HC), and body mass index (BMI) were significantly elevated in the EG compared to the CG (all P < 0.05).NSAT thickness was also markedly greater in the EG (P < 0.05).NSAT thickness was positively correlated with insulin and HOMA-IR, while no significant correlation was found between NSAT and fasting blood glucose (both P > 0.05).Subgroup analysis demonstrated that the correlation between NSAT and IR was more prominent in males and subjects aged over 60 years.Conclusion: NSAT thickness is significantly positively correlated with IR, independent of classic obesity indicators, indicating that neck subcutaneous fat can act as a new imaging biomarker for identifying metabolic abnormalities.
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Shi et al. (2026) conducted a cross-sectional in Overweight and obesity (n=617). Neck subcutaneous adipose tissue (NSAT) thickness in overweight/obese status (BMI ≥ 24 kg/m2) vs. Normal-weight control group (BMI < 24 kg/m2) was evaluated on Correlation between neck subcutaneous adipose tissue (NSAT) thickness and insulin resistance index (HOMA-IR) in overweight and obese patients (r = 0.121, p=0.002). Neck subcutaneous adipose tissue thickness was positively correlated with HOMA-IR (r = 0.121, P = 0.002) and fasting insulin (r = 0.162, P < 0.001) in overweight and obese patients.
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