Key result
Packed cell volume and LVMI were independently associated with eGFR <60 mL/min/1.73m2 in adults with non-dialysis CKD.
Why the study?
Cardiovascular disease contributes significantly to morbidity and mortality in patients with chronic kidney disease. This study evaluated the burden of cardiovascular risk factors and echocardiographic abnormalities and their relationship with eGFR in Nigerian adults with CKD.
Cross-Sectional (n=76)
No
Answers are grounded in this paper and cite their sources.
In Nigerian adults with non-dialysis chronic kidney disease, hypertension, anaemia, proteinuria, and left ventricular hypertrophy are highly prevalent, with packed cell volume and left ventricular mass index independently associated with reduced eGFR (<60 mL/min/1.73m2).
Background: Cardiovascular disease (CVD) is common in patients with chronic kidney disease (CKD) and contributes significantly to morbidity and mortality. This study sought to evaluate the burden of cardiovascular risk factors and echocardiographic abnormalities, and to determine their relationship with estimated glomerular filtration rate (eGFR) in a cohort of Nigerian adults with CKD. Methods: This cross-sectional observational study consecutively recruited 80 adult patients with established, non-dialysis CKD attending the Nephrology and Cardiology outpatient clinics at the Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile-Ife, Nigeria. Clinical evaluations, laboratory investigations, and transthoracic M-mode and Doppler echocardiography were performed. Results: Seventy-six patients (95%) completed all evaluations (46 males, 30 females; mean age 51.32 ± 12.34 years). The observed prevalence rates of cardiovascular risk markers/complications were hypertension (92.1%), anaemia (88.46%), and dipstick proteinuria (98.7%). The prevalence rates of structural abnormalities and clinical cardiovascular conditions were left ventricular hypertrophy (LVH; 69.7%), congestive cardiac failure (CCF; 47.4%), and peripheral vascular disease (PVD; 25.0%). Multivariable logistic regression showed that packed cell volume (PCV) (OR: 3.422; 95% CI: 2.654 – 3.962; P < 0.001) and left ventricular mass index (LVMI) (OR: 0.980; 95% CI: 0.965 – 0.996; p = 0.014) were independently associated with an eGFR < 60 mL/min/1.73m2. Conclusion: Hypertension, anaemia, proteinuria, and LVH were highly prevalent in this CKD cohort, supporting the clinical imperative for systematic cardiovascular risk assessment and management in this population.
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Ogunyemi et al. (2026) conducted a cross-sectional in Chronic kidney disease (n=76). Packed cell volume and left ventricular mass index was evaluated on eGFR < 60 mL/min/1.73m2 (OR 3.422, 95% CI 2.654-3.962, p=< 0.001). Packed cell volume and LVMI were independently associated with eGFR <60 mL/min/1.73m2 in adults with non-dialysis CKD.
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