Key result
Stage-targeted injectable hydrogels optimize myocardial repair across evolving post-infarction phases.
Why the study?
Myocardial infarction triggers a temporally evolving pathological cascade that places distinct and sometimes competing demands on biomaterial intervention at different stages of myocardial repair.
A disease-stage-based framework can guide the design of injectable hydrogels to better align biomaterial properties and therapeutic timing with the evolving pathophysiology of post-MI repair.
Answers are grounded in this paper and cite their sources.
Stage-specific hydrogels may advance post-MI repair strategies; leaves open clinical translation amid delivery and retention barriers.
Myocardial infarction (MI) triggers a temporally evolving cascade of ischemic injury, inflammation, extracellular matrix degradation, fibrosis, and adverse ventricular remodeling. This temporal heterogeneity places distinct, and sometimes competing, demands on biomaterial intervention at different stages of myocardial repair. This review examines injectable hydrogels according to how their material properties and therapeutic functions address the evolving pathology of MI. This review discusses injectable hydrogels in the context of MI progression. The biological features and treatment priorities of the main post-infarction stages are summarized, followed by recent advances in in situ-forming hydrogels, shear-thinning materials, reversible covalent and supramolecular networks, and systems designed for stimulus-responsive or sequential delivery. The distinctions among multifunctional, stimulus-responsive, and programmable hydrogels are clarified, with particular attention to the timing and sequence of therapeutic action. Challenges associated with catheter delivery, myocardial retention, degradation, biosafety, large-animal validation, manufacturing, and clinical translation are also discussed. A disease-stage-based perspective may guide the development of injectable hydrogels that better match the changing needs of post-infarction myocardial repair.
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Chen et al. (2026) conducted a review in Myocardial infarction. Injectable hydrogels was evaluated on Myocardial repair and adverse ventricular remodeling. Injectable hydrogels designed around evolving post-infarction disease stages may better match the temporally changing needs of myocardial repair.
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