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September 1, 2002Experimental PhysiologyOpen Access

Myocardial Infarction and Cardiac Remodelling in Mice

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Population

Male C57BL/6J mice

Design

Preclinical

Follow-up

6 months

Key result

Left anterior descending coronary artery ligation in mice induced progressive cardiac remodelling, with scar formation completed by day 21 and progressive LV dilation up to 6 months.

Authors

FYFang YangYLYunhe LiuXYXiaoping Yang

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Overview

Mouse MI model maps post-infarct remodeling timeline; hypothesis-generating for timed interventions, requires clinical validation.

Key Points

  • This study aims to explore the processes of cardiac remodelling following myocardial infarction in a mouse model.
  • Ligated the left anterior descending coronary artery in male C57BL/6J mice.
  • Assessed healing and left ventricular remodelling at specified time points after myocardial infarction.
  • Performed echocardiography at multiple intervals post injury.
  • Neutrophil infiltration peaked at 1-2 days, marked macrophage infiltration at day 4.
  • Significant LV diastolic dimension increase noted at 2 weeks; shortening fraction decreased over time.
  • In non-infarcted LV regions, myocyte cross-sectional area and interstitial collagen fraction reached a maximum at 4 months.

Structured PICO

P
Population
Male C57BL/6J mice subjected to left anterior descending coronary artery ligation followed for up to 6 months.
I
Intervention
Ligation of the left anterior descending coronary artery to induce myocardial infarction (MI)
O
Outcome
Healing and left ventricular (LV) remodelling assessed at 1, 2, and 4 days and 1, 2, and 4 weeks after MIsurrogate

This preclinical study maps the precise timeline of cellular infiltration, scar formation, and progressive left ventricular remodeling up to 6 months following induced myocardial infarction in a mouse model.

Cite This Study

Yang et al. (2002) studied Myocardial infarction. Left anterior descending coronary artery ligation was evaluated on Healing and left ventricular remodelling. Left anterior descending coronary artery ligation in mice induced progressive cardiac remodelling, with scar formation completed by day 21 and progressive LV dilation up to 6 months.

synapsesocial.com/papers/6a22be8c65451dc9090e2e18https://doi.org/10.1113/eph8702385
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Survival, haemodynamics and cardiac remodelling follow up in mice after myocardial infarction2003 · 13 citations
  2. 2Myocyte injury along myofibers in left ventricular remodeling after myocardial infarction2009 · 11 citations
  3. 3New Strategies for Echocardiographic Evaluation of Left Ventricular Function in a Mouse Model of Long-Term Myocardial Infarction2012 · 62 citations
  4. 4Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in mice2000 · 181 citations
  5. 5Ventricular remodeling in a mouse model of myocardial infarction1998 · 198 citations