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Historical analysis demonstrates how renin affects blood pressure in animals, indicating its importance in renal research.
The history of the discovery of renin in 1896 by Robert Tigerstedt and Per Bergman, the life and creative path of these scientists are described. In animal experiments, they demonstrated that injection of the renal extract to the animals results in a significant increase in blood pressure. Later, they defined the location of renin synthesis (the renal cortex), its physical and chemical characteristics (peptide), analyzed vasoconstriction effect and pharmacokinetics (velocity and duration of the effect).
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В. Н. Хирманов (2025) studied this question.
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