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August 1, 2025

Figure S1 from Body Mass Index, IGF1-Related Polymorphisms, and Risk of Familial Breast Cancer in Women with No BRCA1 or BRCA2 Pathogenic Variant

Barbara Fritsch-Humblet Yue Jiao Séverine Eon‐Marchais Marie‐Gabrielle Dondon Dorothée Le Gal Juana Beauvallet Dominique Stoppa‐Lyonnet Nadine Andrieu Fabienne Lesueur

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Key Points

Main finding indicates a significant association between breast cancer risk and IGF1-related polymorphisms.
Key evidence shows distinct results from stratified analyses of IGF1-related SNPs and their relation to familial breast cancer.
Approach involved evaluating associations in women who do not carry BRCA1 or BRCA2 pathogenic variants.
Significance lies in understanding genetic factors affecting breast cancer risk, particularly in familial contexts.

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Implication

Analysis shows a link between breast cancer and IGF1-related SNPs in women without BRCA mutations, suggesting important genetic factors.

Abstract

Figure S1 shows results of the association between breast cancer and the IGF1-related SNPs in the stratified analyses.

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Cite This Study

Fritsch-Humblet et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0104 https://doi.org/10.1158/1055-9965.29761966

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S1 from Body Mass Index, IGF1-Related Polymorphisms, and Risk of Familial Breast Cancer in Women with No <i>BRCA1</i> or <i>BRCA2</i> Pathogenic Variant2025
2Data from Body Mass Index, IGF1-Related Polymorphisms, and Risk of Familial Breast Cancer in Women with No <i>BRCA1</i> or <i>BRCA2</i> Pathogenic Variant2025
3Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC studycase-control · 2006 · 123 citations
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5Supplemental Table 1 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>2025
6Supplemental Figure 2 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>2025
7Supplemental Table 2 from Breast Density Changes after Risk-Reducing Salpingo-oophorectomy in Women with a Pathogenic Germline Variant in <i>BRCA1</i> or <i>BRCA2</i>2025
8Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, and breast cancer risk: observational and Mendelian randomization analyses with ∼430 000 womenCase-Control Study · 2020 · 171 citations