August 2, 2025

Supplementary Figure 7 from Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

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MAIN FINDING: Epigenetic heritability influences cell plasticity, affecting cancer drug resistance mechanisms.
KEY EVIDENCE: Changes in allele frequency were observed in organoids treated with capivasertib and trametinib.
APPROACH: The study utilized organoid models to investigate genotype-to-phenotype relationships in cancer treatment.
SIGNIFICANCE: Understanding these pathways may help develop better strategies to combat cancer drug resistance.

Implication

Analysis reveals allele frequency shifts in organoids treated with capivasertib and trametinib, suggesting pathways for cancer drug resistance.

Allele frequency distribution in parental vs capivasertib->trametinib treated organoids

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Oliveira et al. (2025) studied this question.

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Analysis reveals allele frequency shifts in organoids treated with capivasertib and trametinib, suggesting pathways for cancer drug resistance.

Allele frequency distribution in parental vs capivasertib->trametinib treated organoids