August 2, 2025

Supplementary Figure 5 from Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

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MAIN FINDING: Epigenetic heritability influences cell plasticity, contributing to cancer drug resistance.
KEY EVIDENCE: Relative fitness distribution was computed from floating barcodes representing cancer cell populations.
APPROACH: The study analyzed the fitness of various cancer cell phenotypes under drug treatment conditions.
SIGNIFICANCE: Understanding drug resistance mechanisms could improve cancer treatment strategies and outcomes.

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Experimental analysis reveals relative fitness distribution in cancer cells, suggesting genotype-to-phenotype shifts drive drug resistance.

Relative fitness distribution computed over floating barcodes abundance

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Oliveira et al. (2025) studied this question.

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Experimental analysis reveals relative fitness distribution in cancer cells, suggesting genotype-to-phenotype shifts drive drug resistance.

Relative fitness distribution computed over floating barcodes abundance