August 2, 2025

Supplementary Figure 10 from Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

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MAIN FINDING: Epigenetic heritability significantly influences cell plasticity, contributing to cancer drug resistance.
KEY EVIDENCE: Analysis of marker gene expression reveals distinct patterns related to drug resistance in colon cells.
APPROACH: UMAP feature plots were used to visualize the underlying genotype-to-phenotype relationships.
SIGNIFICANCE: Understanding these mechanisms can inform new strategies for overcoming drug resistance in cancer treatment.

Implication

Analysis demonstrates the role of epigenetic heritability and cell plasticity in cancer drug resistance, suggesting new therapeutic targets.

Normalised expression for a set of marker genes for colon cell and UMAP feature plots

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Oliveira et al. (2025) studied this question.

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Analysis demonstrates the role of epigenetic heritability and cell plasticity in cancer drug resistance, suggesting new therapeutic targets.

Normalised expression for a set of marker genes for colon cell and UMAP feature plots