August 2, 2025

Supplementary Figure 11 from Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

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MAIN FINDING: Epigenetic heritability impacts cancer drug resistance through cell plasticity.
KEY EVIDENCE: Organoids treated with Oxaliplatin and SCH77298 show significant changes in their transcriptional landscape.
APPROACH: The study utilized organoid models to explore genotype-to-phenotype relationships under drug treatment.
SIGNIFICANCE: These findings enhance understanding of cancer treatment resistance and potential therapeutic strategies.

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Implication

Transcriptional landscape analysis reveals cell plasticity's role in drug resistance in organoids treated with Oxaliplatin and SCH77298, indicating complex genotype-to-phenotype relationships.

Abstract

Transcriptional Landscape of organoids treated with Oxaliplatin and SCH77298

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Oliveira et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02cd https://doi.org/10.1158/0008-5472.29759803

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Implication

Transcriptional landscape analysis reveals cell plasticity's role in drug resistance in organoids treated with Oxaliplatin and SCH77298, indicating complex genotype-to-phenotype relationships.

Abstract

Transcriptional Landscape of organoids treated with Oxaliplatin and SCH77298

Supplementary Figure 11 from Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 11 from Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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