August 2, 2025

Supplementary Figure 2 from Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

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MAIN FINDING: Epigenetic heritability significantly contributes to cancer drug resistance through cellular changes.
KEY EVIDENCE: Drug response curves reveal resistant organoids display different characteristics than sensitive ones.
APPROACH: The study utilized organoid models to explore the genotype-to-phenotype relationship in cancer cells.
SIGNIFICANCE: Understanding this process could lead to better treatments for drug-resistant cancers.

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This research demonstrates drug resistance patterns in organoids, suggesting epigenetic factors influence phenotype expression.

Drug response curves of the resistant organoids

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Oliveira et al. (2025) studied this question.

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This research demonstrates drug resistance patterns in organoids, suggesting epigenetic factors influence phenotype expression.

Drug response curves of the resistant organoids