August 2, 2025

Supplementary Figure 13 from Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

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MAIN FINDING: Epigenetic heritability of cell plasticity significantly contributes to cancer drug resistance.
KEY EVIDENCE: Analysis of TCGA colorectal cancer samples highlighted varied archetype compositions affecting treatment outcomes.
APPROACH: The research utilized genotype-to-phenotype frameworks to explore relationships in cell composition.
SIGNIFICANCE: Understanding this dynamic can lead to improved cancer therapies by targeting cell plasticity mechanisms.

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Observations reveal cell plasticity's impact on cancer drug resistance in colorectal cancer, suggesting a complex genotype-to-phenotype relationship.

Cell type and Archetype composition in TCGA Colorectal Cancer samples

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Oliveira et al. (2025) studied this question.

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Observations reveal cell plasticity's impact on cancer drug resistance in colorectal cancer, suggesting a complex genotype-to-phenotype relationship.

Cell type and Archetype composition in TCGA Colorectal Cancer samples