August 2, 2025

Supplementary Figure 12 from Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

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MAIN FINDING: Epigenetic heritability significantly drives cell plasticity, which contributes to cancer drug resistance.
KEY EVIDENCE: Analysis of progeny pathway and transcriptional factor scores illustrates variation in drug response.
APPROACH: Data was derived from examining archetypes and associated pathway scores to understand drug resistance mechanisms.
SIGNIFICANCE: This insight into genotype-to-phenotype relationships can guide more effective cancer treatment strategies.

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Supplementary data shows how epigenetic heritability influences cancer drug resistance via cell plasticity and archetypes.

Normalised Progeny pathway and transcriptional factor scores by archetypes

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Oliveira et al. (2025) studied this question.

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Supplementary data shows how epigenetic heritability influences cancer drug resistance via cell plasticity and archetypes.

Normalised Progeny pathway and transcriptional factor scores by archetypes