Supplementary Figure S1 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

The core finding shows that genetic control varies by cell subtype in colorectal cancer.
Data from single-cell RNA sequencing of 130 multistage tissues supports this genetic variation.
The analysis focused on eQTL (expression quantitative trait loci) to identify genetic influences.
Understanding subtype-specific mechanisms may improve targeted therapies for colorectal cancer.

Single-cell eQTL mapping reveals cell subtype-specific genetic control in colorectal cancer, highlighting mechanisms of malignant transformation.

Supplementary Figure 1 shows the information of single-cell RNA sequencing data of 130 multistage tissues.

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Chen et al. (2025) studied this question.

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