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August 4, 2025

Figure S1 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis

Sheue‐Fen Tzeng Yi-Ru Yu Jaeoh Park Janusz von Renesse Huey-Wen Hsiao Chen-Hsuan Hsu Josep Garnica Jintian Chen Lu-Ting Chiu Jonas Santol Tse-Yu Chen Pei-Han Chung Lana E. Kandalaft Patrick Starlinger Cheng‐En Hsieh Ming‐Chin Yu Pei‐Wen Hsiao Santiago J. Carmona Hung-Kai Chen Zhen Meng Yun-Han Lin Jingying Zhou Chin‐Hsien Tsai Ping‐Chih Ho

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Key Points

MAIN FINDING: PLT012, a humanized CD36-blocking antibody, is effective in boosting antitumor immunity against liver cancer.
KEY EVIDENCE: Treatment resulted in significant tumor reduction in syngeneic murine models, supporting its antitumor properties.
APPROACH: The study assessed the effects of PLT012 through experiments with subcutaneous tumors in murine models.
SIGNIFICANCE: This research highlights a promising immunotherapy approach for treating liver cancer and metastasis.

Implication

Evaluation of PLT012 treatment showed improved antitumor immunity in murine models with liver cancer, indicating potential therapeutic benefits.

Abstract

The effects of PLT012 treatment were evaluated in subcutaneous tumors using syngeneic murine models.

Discussion

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Cite This Study

Tzeng et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d094c https://doi.org/10.1158/2159-8290.29819671

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S2 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
2Figure S3 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
3Figure S6 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
4Figure S5 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
5Figure S7 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025