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August 4, 2025

Figure S3 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis

Sheue‐Fen Tzeng Yi-Ru Yu Jaeoh Park Janusz von Renesse Huey-Wen Hsiao Chen-Hsuan Hsu Josep Garnica Jintian Chen Lu-Ting Chiu Jonas Santol Tse-Yu Chen Pei-Han Chung Lana E. Kandalaft Patrick Starlinger Cheng‐En Hsieh Ming‐Chin Yu Pei‐Wen Hsiao Santiago J. Carmona Hung-Kai Chen Zhen Meng Yun-Han Lin Jingying Zhou Chin‐Hsien Tsai Ping‐Chih Ho

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Key Points

PLT012, a humanized CD36-blocking antibody, enhances antitumor immunity against liver cancer.
The study characterizes tumor-infiltrating lymphocytes and gene signatures following treatment with PLT012.
Liver cancer mouse models showed increased immune activity against tumors post-PLT012 administration.
These findings provide insights for potential therapeutic strategies targeting liver cancer and metastasis.

Implication

Treatment with PLT012 boosts antitumor immunity in liver cancer models, suggesting new therapeutic avenues for liver metastasis.

Abstract

Characterization for TILs population and gene signatures in liver cancer mouse models following PLT012 treatment.

Discussion

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Cite This Study

Tzeng et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0967 https://doi.org/10.1158/2159-8290.29819665

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S1 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
2Figure S2 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
3Figure S5 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
4Figure S4 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
5Figure S6 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025