Figure S7 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis

Sheue‐Fen Tzeng; Yi-Ru Yu; Jaeoh Park; Janusz von Renesse; Huey-Wen Hsiao; Chen-Hsuan Hsu; Josep Garnica; Jintian Chen; Lu-Ting Chiu; Jonas Santol; Tse-Yu Chen; Pei-Han Chung; Lana E. Kandalaft; Patrick Starlinger; Cheng‐En Hsieh; Ming‐Chin Yu; Pei‐Wen Hsiao; Santiago J. Carmona; Hung-Kai Chen; Zhen Meng; Yun-Han Lin; Jingying Zhou; Chin‐Hsien Tsai; Ping‐Chih Ho

doi:10.1158/2159-8290.29819653

Key Points

MAIN FINDING: A humanized CD36-blocking antibody effectively enhances antitumor immunity against liver cancer.
KEY EVIDENCE: The immune profile assessed indicates significant improvements in tumor immunity following treatment.
APPROACH: A specific gating strategy was utilized to analyze the immune responses in human HCC tumor tissues.
SIGNIFICANCE: This research suggests that targeting CD36 may provide new therapeutic strategies for liver cancer and metastasis.

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Implication

Assessing the immune profile reveals that a CD36-blocking antibody improves antitumor immunity against liver cancer, indicating its potential in treating metastasis.

Abstract

Gating Strategy employed to assess the immune profile in human HCC tumor tissue.

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Tzeng et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d095f https://doi.org/10.1158/2159-8290.29819653

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Figure S7 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Figure S7 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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