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August 4, 2025

Figure S2 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis

Sheue‐Fen Tzeng Yi-Ru Yu Jaeoh Park Janusz von Renesse Huey-Wen Hsiao Chen-Hsuan Hsu Josep Garnica Jintian Chen Lu-Ting Chiu Jonas Santol Tse-Yu Chen Pei-Han Chung Lana E. Kandalaft Patrick Starlinger Cheng‐En Hsieh Ming‐Chin Yu Pei‐Wen Hsiao Santiago J. Carmona Hung-Kai Chen Zhen Meng Yun-Han Lin Jingying Zhou Chin‐Hsien Tsai Ping‐Chih Ho

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Key Points

MAIN FINDING: PLT012 effectively boosts antitumor immunity against liver cancer and liver metastasis.
KEY EVIDENCE: Treated HCC mouse models showed significant immune response enhancement with PLT012 therapy.
APPROACH: The study utilized in vivo distribution assays in a mouse model of hepatocellular carcinoma (HCC).
SIGNIFICANCE: This finding could advance treatment strategies for patients with liver cancer and improve survival rates.

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Implication

In vivo testing of PLT012 improves antitumor immunity in liver cancer models, indicating a potential for cancer therapy.

Abstract

In vivo distribution assay for PLT012 treatment in HCC mouse model.

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Cite This Study

Tzeng et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d094e https://doi.org/10.1158/2159-8290.29819668

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S1 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
2Figure S3 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
3Figure S7 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
4Figure S5 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025
5Figure S6 from PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis2025