Supplementary Figure S5 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: The study identifies genetic control of cell subtype-specific mechanisms involved in colorectal cancer.
KEY EVIDENCE: Clustering of spatial transcriptomic spots allows for definition of cell types across different cancer stages.
APPROACH: Unbiased clustering techniques were applied to analyze spatial transcriptomic data from colorectal cancer samples.
SIGNIFICANCE: Insights from this research may enhance understanding of malignant transformation in cancer and inform targeted therapies.

Supplementary figure reveals spatial transcriptomics and cell types in colorectal cancer samples, indicating specific genetic control mechanisms.

Supplementary Figure 5 shows unbiased clustering of spatial transcriptomic spots and define cell types of each cluster for four stage samples.

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Chen et al. (2025) studied this question.

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