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September 5, 2025Open Access

Table S10 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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Loss of NF1 leads to increased EGFR activation and enhances sensitivity to EGFR inhibition, providing a potential target.
The study shows a differential analysis of H3K3Me3 comparing shNF1 to shScramble underlines a significant interaction between NF1 loss and EGFR pathways.
Differential analysis was conducted using H3K3Me3 markers, providing insights into the epigenetic changes due to NF1 loss.
Findings may indicate the need for tailored approaches in treating patients with NF1-mutant melanoma.

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Differential analysis of H3K3Me3 reveals that NF1 loss increases EGFR activation in NF1-mutant melanoma, suggesting possible therapeutic targets.

H3K3Me3 differential analysis shNF1 vs shScramble

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Ibrahim et al. (2025) studied this question.

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Differential analysis of H3K3Me3 reveals that NF1 loss increases EGFR activation in NF1-mutant melanoma, suggesting possible therapeutic targets.

H3K3Me3 differential analysis shNF1 vs shScramble