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September 5, 2025Open Access

Table S7 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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EGFR activation is significantly higher in NF1 mutant melanoma compared to wild type.
This activation correlates with increased sensitivity to EGFR inhibition therapy.
Findings indicate a potential therapeutic strategy targeting EGFR in NF1 mutant melanoma.
Improvement in treatment outcomes may be observed with EGFR inhibitors in these patients.

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Analysis reveals increased EGFR activation in NF1 mutant melanoma, suggesting potential targeted therapies.

H-Score of EGFR expression in NF1 mutant and NF1 wild type biospecimen

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Ibrahim et al. (2025) studied this question.

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Analysis reveals increased EGFR activation in NF1 mutant melanoma, suggesting potential targeted therapies.

H-Score of EGFR expression in NF1 mutant and NF1 wild type biospecimen