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September 5, 2025Open Access

Table S2 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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NF1 loss enhances EGFR activation, leading to increased sensitivity to EGFR inhibitors.
Gene expression analysis shows marked differences between NF1 mutant and wild type samples.
The findings derive from a comparative assessment of mutant and wild type NF1 melanoma models.
These results imply new avenues for targeted therapies in NF1-mutant melanoma patients.

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Differential gene expression affects EGFR activity in NF1-mutant melanoma, suggesting treatment strategies.

Differential gene expression of NF1 mutant vs 19 NF1 wild type

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Ibrahim et al. (2025) studied this question.

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Differential gene expression affects EGFR activity in NF1-mutant melanoma, suggesting treatment strategies.

Differential gene expression of NF1 mutant vs 19 NF1 wild type