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September 5, 2025Open Access

Table S5 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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EGFR activation leads to increased sensitivity to inhibition in NF1-mutant melanoma, enhancing treatment potential.
Key evidence reveals distinct gene expression patterns in NF1 mutant compared to wild type, impacting therapeutic strategies.
The study employs KEGG pathway analysis of differentially expressed genes to explore functional implications in melanoma.
These findings suggest that targeting EGFR may provide improved strategies for managing NF1-related melanoma.

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KEGG pathway analysis highlights EGFR activation in NF1-mutant melanoma, suggesting effective targeting with inhibition.

KEGG pathway analysis of DEGs NF1 mutant vs NF1 wild type

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Ibrahim et al. (2025) studied this question.

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KEGG pathway analysis highlights EGFR activation in NF1-mutant melanoma, suggesting effective targeting with inhibition.

KEGG pathway analysis of DEGs NF1 mutant vs NF1 wild type