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September 2, 2025Open Access

Table S12 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

Milad Ibrahim Irineu Illa-Bochaca George Jour Eleazar Vega‐Saenz de Miera Joseph Fracasso Kelly V. Ruggles Iman Osman Markus Schöber

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Key Points

NF1 loss enhances EGFR activation and sensitivity to treatment with cetuximab in melanoma.
Pathway analysis identified differentially expressed genes (DEGs) between cetuximab and IgG in PDX models.
Findings point to the importance of NF1 in melanoma pathology and possible treatment strategies.
The results suggest targeting EGFR could be a viable option for patients with NF1-mutant melanoma.

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Implication

Analysis shows enhanced EGFR activity and sensitivity to cetuximab in NF1-mutant melanoma, indicating potential therapeutic targets.

Abstract

GSEA pathway analysis of DEGs Cetuximab vs IgG PDX models

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Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02b05 https://doi.org/10.1158/0008-5472.30029870

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S5 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
2Table S9 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
3Table S2 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
4Table S3 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
5Table S8 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025