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September 5, 2025Open Access

Table S3 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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EGFR activation is enhanced by NF1 loss, leading to increased sensitivity to EGFR inhibitors.
Analysis shows differential alterations in chromatin accessibility related to EGFR activation.
ATAC Seq was used to assess chromatin accessibility in NF1-mutant melanoma samples.
Findings highlight the role of NF1 loss in modulating response to EGFR-targeted therapies.

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Differential analysis reveals EGFR activation in NF1-mutant melanoma, indicating potential treatment sensitivities.

ATAC Seq differential analysis

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Ibrahim et al. (2025) studied this question.

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Differential analysis reveals EGFR activation in NF1-mutant melanoma, indicating potential treatment sensitivities.

ATAC Seq differential analysis