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September 5, 2025Open Access

Figure S4 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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NF1 loss enhances EGFR H3K4Me3 promoter activity, leading to increased EGFR activation.
The activation of EGFR due to NF1 loss makes melanoma cells more sensitive to EGFR inhibition.
Findings indicate a potential therapeutic target for NF1-mutant melanoma through EGFR inhibition.
Further exploration could unveil critical pathways for enhancing treatment strategies against melanoma.

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Loss of NF1 increases EGFR activity in melanoma, suggesting it plays a role in treatment sensitivity to EGFR inhibitors.

NF1 loss induces EGFR H3K4Me3 promoter activity

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Ibrahim et al. (2025) studied this question.

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Loss of NF1 increases EGFR activity in melanoma, suggesting it plays a role in treatment sensitivity to EGFR inhibitors.

NF1 loss induces EGFR H3K4Me3 promoter activity