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September 2, 2025Open Access

Supplementary Fig. S7 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis

Yongding Wu Xiaoxiao Huang Haoxiang Zhang Yu Pan Cheng-Ke Xie Ge Li Cai‐Feng Lin Xiaoyan Lin Zhi-Yuan Li Yin-Hao Chen Jian-Fei Hu Hong-Yi Lin Shun‐Cang Zhu Zuwei Wang Yi-Feng Tian Qiao-Wei Li Cheng‐Yu Liao Shi Chen

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Key Points

TRAF3IP2-AS1 deficiency induces necroptosis, driving pancreatic cancer liver metastasis, which is a serious complication.
Ubiquitination of PPM1B through TRAF3IP2 plays a crucial role in this mechanism, influencing metastatic progression.
Observational analysis highlights the relationship between TRAF3IP2-AS1 and the aggressive behavior of pancreatic tumors.
Understanding this mechanism supports potential therapeutic strategies targeting necroptosis in pancreatic cancer.

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Implication

Analysis shows TRAF3IP2-AS1 deficiency fosters necroptosis leading to liver metastasis in pancreatic cancer, highlighting the role of ubiquitination.

Abstract

Supplementary Fig. S7 TRAF3IP2-AS1 deficiency regulates PPM1B ubiquitination through TRAF3IP2

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Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f600 https://doi.org/10.1158/0008-5472.30029089

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig. S8 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
2Supplementary Fig. S3 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
3Supplementary Fig. S5 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
4Supplementary Fig. S2 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
5Supplementary Fig. S4 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025

Supplementary Fig. S6 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
Data from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
Supplementary Fig. S1 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025