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September 2, 2025Open Access

Supplementary Fig. S6 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis

Yongding Wu Xiaoxiao Huang Haoxiang Zhang Yu Pan Cheng-Ke Xie Ge Li Cai‐Feng Lin Xiaoyan Lin Zhi-Yuan Li Yin-Hao Chen Jian-Fei Hu Hong-Yi Lin Shun‐Cang Zhu Zuwei Wang Yi-Feng Tian Qiao-Wei Li Cheng‐Yu Liao Shi Chen

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Key Points

TRAF3IP2-AS1 deficiency induces necroptosis, promoting liver metastasis in pancreatic cancer.
IGF2BP2 was shown to augment MLKL mRNA stability, linked to the m6A pathway's involvement.
This analysis identified a significant relationship between mRNA stability and pancreatic cancer progression.
Understanding this mechanism could inform novel therapeutic strategies targeting necroptosis.

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Implication

Analysis shows necroptosis enhances liver metastasis in pancreatic cancer, suggesting IGF2BP2 stabilizes MLKL mRNA via the m6A pathway.

Abstract

Supplementary Fig. S6 IGF2BP2 augments the stability of MLKL mRNA via the m6A pathway

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Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f602 https://doi.org/10.1158/0008-5472.30029095

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig. S8 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
2Supplementary Fig. S7 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
3Supplementary Fig. S3 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
4Supplementary Fig. S4 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
5Supplementary Fig. S5 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025

Supplementary Fig. S2 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
Data from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
Supplementary Fig. S1 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025