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September 2, 2025Open Access

Supplementary Fig. S2 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis

Yongding Wu Xiaoxiao Huang Haoxiang Zhang Yu Pan Cheng-Ke Xie Ge Li Cai‐Feng Lin Xiaoyan Lin Zhi-Yuan Li Yin-Hao Chen Jian-Fei Hu Hong-Yi Lin Shun‐Cang Zhu Zuwei Wang Yi-Feng Tian Qiao-Wei Li Cheng‐Yu Liao Shi Chen

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Key Points

TRAF3IP2-AS1 deficiency promotes necroptosis, leading to increased liver metastasis in pancreatic cancer.
Key evidence includes the observation of necroptosis induction associated with TRAF3IP2-AS1 loss in PDAC.
This study conducted an analysis focused on the lncRNA TRAF3IP2-AS1 and its regulatory role in necroptosis.
The findings highlight the importance of TRAF3IP2-AS1 in pancreatic cancer progression, particularly in liver metastasis.

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Implication

Observational data shows TRAF3IP2-AS1 deficiency enhances necroptosis in PDAC, suggesting a role in liver metastasis.

Abstract

Supplementary Fig. S2 The identification of the necroptosis-regulating lncRNA TRAF3IP2-AS1 in PDAC

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Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f66b https://doi.org/10.1158/0008-5472.30029116

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig. S3 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
2Supplementary Fig. S8 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
3Supplementary Fig. S7 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
4Supplementary Fig. S5 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
5Data from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
6Supplementary Fig. S4 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
7Supplementary Fig. S6 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
8Supplementary Fig. S1 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025