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September 2, 2025Open Access

Supplementary Fig. S4 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis

Yongding Wu Xiaoxiao Huang Haoxiang Zhang Yu Pan Cheng-Ke Xie Ge Li Cai‐Feng Lin Xiaoyan Lin Zhi-Yuan Li Yin-Hao Chen Jian-Fei Hu Hong-Yi Lin Shun‐Cang Zhu Zuwei Wang Yi-Feng Tian Qiao-Wei Li Cheng‐Yu Liao Shi Chen

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Key Points

Deficiency of TRAF3IP2-AS1 induces necroptosis, contributing to pancreatic cancer liver metastasis.
Necroptosis observed significantly enhances M2-like macrophage polarization via TGFβ1 release.
Observational analysis of macrophage behavior demonstrates the impact of neoplastic processes on immune interactions.
This finding highlights potential therapeutic targets for managing metastasis in pancreatic cancer.

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Implication

Supplementary analysis reveals necroptosis facilitates M2-like macrophage polarization through TGFβ1 release.

Abstract

Supplementary Fig. S4 TRAF3IP2-AS1 deficiency-induced necroptosis promotes M2-like macrophage polarization through the release of TGFβ1

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Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5e0 https://doi.org/10.1158/0008-5472.30029110

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Keep reading

Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig. S5 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
2Supplementary Fig. S3 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
3Supplementary Fig. S8 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
4Supplementary Fig. S7 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
5Supplementary Fig. S2 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
6Data from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
7Supplementary Fig. S6 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
8Supplementary Fig. S1 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025