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September 2, 2025Open Access

Supplementary Fig. S3 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis

Yongding Wu Xiaoxiao Huang Haoxiang Zhang Yu Pan Cheng-Ke Xie Ge Li Cai‐Feng Lin Xiaoyan Lin Zhi-Yuan Li Yin-Hao Chen Jian-Fei Hu Hong-Yi Lin Shun‐Cang Zhu Zuwei Wang Yi-Feng Tian Qiao-Wei Li Cheng‐Yu Liao Shi Chen

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Key Points

Necroptosis is significantly induced by TRAF3IP2-AS1 deficiency, leading to increased metastatic potential.
The study found that pancreatic cancer cells experience elevated necroptosis, enhancing their spread to the liver.
Assessment of cellular pathways revealed that TRAF3IP2-AS1 plays a crucial role in regulating necroptotic cell death.
Understanding this mechanism highlights potential therapeutic targets for preventing liver metastasis in pancreatic cancer.

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Implication

Observational analysis shows necroptosis increasing liver metastasis in pancreatic cancer, suggesting a novel pathway for intervention.

Abstract

Supplementary Fig. S3 TRAF3IP2-AS1 deficiency leads to necroptosis in PDAC.

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Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f66e https://doi.org/10.1158/0008-5472.30029113

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig. S8 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
2Supplementary Fig. S2 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
3Supplementary Fig. S7 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
4Supplementary Fig. S5 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
5Supplementary Fig. S4 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025

Data from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
Supplementary Fig. S1 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025
Supplementary Fig. S6 from TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis2025