Supplementary Figure S6 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Kanakaraju Manupati; Mingang Hao; Suhua Li; Sushma Maharjan; Jun‐Lin Guan

doi:10.1158/1541-7786.30050734

September 4, 2025

Supplementary Figure S6 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

View at Publisher

Ask AI

Bookmark

Share

Key Points

Rapamycin treatment significantly affects 4E-BP1 phosphorylation and migration in PI3KC2β knockout cells.
The observed impact of rapamycin suggests mTORC1 signaling is crucial for metastasis regulation.
Supplementary findings indicate a novel role of PI3KC2β in breast cancer biology.
Further exploration of mTORC1 can enhance understanding of breast cancer metastasis.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Supplementary figure shows rapamycin's effects on 4E-BP1 phosphorylation and migration in PI3KC2β KO cells, indicating PI3KC2β's role in breast cancer metastasis.

Abstract

Supplementary Figure S6 shows effect of rapamycin on 4E-BP1 phosphorylation and migration of PI3KC2β KO cells.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Manupati et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a061482e https://doi.org/10.1158/1541-7786.30050734

View at Publisher

Ask AI

Bookmark

Share

Supplementary Figure S6 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S6 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading